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Additionally, mast cell activation can occur by IgG-antigen complexes, pathogen-associated molecular patterns (PAMPS), cell-cell contact, and hormones.[ref] Mast cell release exosomes and microRNAs: In addition to degranulating, mast cells also communicate with other cells by secreting mediators and by releasing exosomes

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Epub 2011 Jan 19

It is most often studied in animal models of tendon, gut, and vessel injury, and is not an FDA-approved drug

as this was exploratory there were no study size decisions made a priori