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It's a good idea to avoid astaxanthin if you: Are pregnant Have autoimmune problems Take immunosuppressant medication Have allergies to carotenoids Take medicines inhibiting 5-alpha-reductase Always talk to your doctor before starting the supplement

It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)

Zheng S, Deng Z, Chen F, Zheng L, Pan Y, Xing Q, et al

Planta 248:963979

This hypocholesterolemic effect is achieved by lowering both plasma and liver cholesterol levels through the increased action of lipoprotein lipase and hepatic triglyceride lipase (45)

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