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W., Ye, L., Sabatini, D

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Both cross the bloodbrain barrier and have been shown to lower nighttime cortisol by dampening the hypothalamicpituitaryadrenal (HPA) axis, which in turn reduces stressinduced awakenings

Beyond pharmacokinetic and methodological constraints, regulatory barriers further impede the clinical translation of natural compounds for AD therapy

Lee WM, Senior JR