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NAC has been elucidated to interact with numerous metabolic pathways including, regulation of the cell cycle and apoptosis, carcinogenesis and tumor progression, mutagenesis, gene expression and signal transduction, immune modulation, cytoskeleton organization and trafficking and mitochondrial functions [4]Huang R, Pan Q, Ma X et al

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Furthermore, the severity and incidence of HACE may be influenced by physiological processes related to ubiquitination and polymorphisms of key enzymes [7]

Bioorg Chem 128:106101