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190 These studies suggest that promoting ferroptosis is a promising strategy to overcome drug resistance in colon cancer patients

In one study, researchers found that bilirubin significantly inhibited autophagy in the human colon adenocarcinoma cell lines of LS180 and SW480 cells by suppressing Beclin-1 and Microtubule-Associated Protein 1 Light Chain 3B (LC-3B) in the cells, and increased apoptosis by the upregulation of p53 in LS180 cells and downregulation of the Bcl-2 gene which inhibits apoptosis in SW480 cells (85)

Targeting BCL-2 regulated apoptosis in cancer

These compounds are not yet FDA-approved and most human evidence is still very limited

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