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Another study reported that, in children with fever, the area under the serum concentration-time curve (AUC) increased by 1344% from first dose to steady state implying that paracetamol may accumulate in this patient group although no hepatotoxicity was demonstrated [48]

Giovannoni F, Quintana FJ

DAO is located only in certain organs in the body: the small intestine, ascending colon, kidney, liver and placenta

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Additionally, the FOXO4-p53 interaction contributes to the maintenance of senescent cells by activating the transcription of their common target gene, p21cip1, which suppresses apoptosis 36