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Dosage: 1000 mcg per week (split into 2-3 doses) via subcutaneous injection

For people with type 2 diabetes, the SURPASS trial series demonstrated exceptional glycemic control alongside weight loss, which is why the compound received its first approval for diabetes before the obesity indication followed

There is no validated, publicly available reconstitution protocol for individuals to follow safely

Even with fortified foods and supplements, that 88% deficiency statistic shows how common this problem is in plant-based eaters

The American Journal of Pathology, 173(1), 7792

Medically Reviewed Written by: Kia Michel, MD, Board-Certified Urologist, Urological Surgeon, & Sexual Health Specialist Reviewed by: Robert Sanford, MD, Board-Certified Urologist, Urological Surgeon, & Sexual Health Specialist Last Reviewed: March 02, 2026 12:50 pm PT How We Review Medical Content: Dr