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Histologic Analysis HE and MT Staining Lung tissues were fixed in 4% paraformaldehyde for 24 h, dehydrated in an ethanol gradient, and embedded in paraffin

However, the differences in the UPDRS I (SMD, -0.04

Taken together, these results support a model in which metformin suppresses TXNIP expression not through AMPK activation, but via mitochondrial complex I inhibition, leading to increased NADPH production, enhanced antioxidant gene expression and ROS reduction

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