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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Sowden H.M., Karoo R.O.S., Tobin D.J

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No adverse effects were reported at therapeutic doses during the study period

Particularly when its chronic, patients often wind up in kidney failure and on dialysis, which has basic scientists and physicians alike looking for better interventions

As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

The Role of Brain-Reactive Autoantibodies in Brain Pathology and Cognitive Impairment