At 42 hours after conditioning, control diazepam-treated rats showed shortened preconvulsive latencies (indicating tolerance), while BPC-157 groups maintained longer latencies with prolonged residual anticonvulsive activity
Second, as an observational study, causality cannot be established, and the findings remain susceptible to residual confounding from unmeasured factors, including confounding by indication, disease severity, prescribing preferences, and lifestyle factors such as diet, physical activity, or cognitive engagement
PMID 2080048
This may also be due to the autoimmune attack on the parietal cells of the stomach in pernicious anemia
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Unlike benzodiazepines or other sedatives, it doesn't appear to create tolerance requiring escalating doses or produce withdrawal symptoms upon cessation