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This review has delineated the anatomical and pathophysiological basis of rotator cuff-associated muscle atrophy, with a particular focus on the pivotal role of ROS in mediating oxidative damage, mitochondrial dysfunction, myofiber apoptosis, and activation of key catabolic signaling cascades, including the FOXO, NF-B, and MAPK pathways

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doi: 10.3892/mmr.2016.4807 201 BogavacMJakovljeviANikoliAMiloevi ToiMPeriTBelopavloviZ

Myelin splitting, Schwann cell injury and demyelination in feline diabetic neuropathy