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Steinberg MH

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

Verdict: Limited evidence human endocrine studies are small or indirect, and DSIP has not been proven as an anxiety or cortisol-lowering therapy [810]

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However, given its potential effects on recovery and performance, it could attract regulatory attention in the future