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"MOTS-c levels in human blood decline with age and correlate with insulin sensitivity, positioning the peptide not just as a metabolic tool but as a potential biomarker of mitochondrial vitality." On the exercise side, a pivotal finding came from studies measuring endogenous MOTS-c in human subjects

Pharm Biol

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4c ) release anti-inflammatory cytokines such as IL-4 and IL-10 as well as transforming growth factor- (TGF- ), IGF-1 and BDNF, which in turn enhance neurogenesis [91, 98, 106]

Better circulation to skin and connective tissue directly supports the delivery of nutrients and growth factors that tissue remodeling depends on

It can target senescent cells