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A peptide that survives the stomach still faces intestinal brush border peptidases, limited transepithelial transport, and hepatic first-pass metabolism

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Imatinib-induced GPX4 proteasomal degradation Imatinib is a tyrosine kinase inhibitor designed to inhibit BCR-ABL activity in chronic myelogenous leukemia (CML) that revolutionized the treatment of this hematopoietic malignancy in the early 2000s [46]