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The FDA approved tirzepatide under two brand names: Mounjaro for type 2 diabetes and Zepbound for obesity

Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools

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Mechanism: Semaglutide works primarily through appetite suppression by acting on GLP-1 receptors in the brain and gut

Thus, it appears important to evaluate vitamin B 12 status, as well as kidney function, in older individuals with elevated homocysteine levels prior to initiating homocysteine-lowering therapy

Clinical Scenarios for IV Administration IV B12 is very helpful in some situations, like when the deficiency is severe and causing neurological problems, in cases of malabsorption like Crohns disease, or when taking pills doesnt work