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Excessive methionine intake in the presence of inadequate intake of folic acid , vitamin B6 , and vitamin B12 , can increase the conversion of methionine to homocysteine , a substance linked to heart disease and stroke

Accessed December 15, 2025

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[3] The British Society for Haematology guidelines emphasise that the response to treatment should be monitored through clinical assessment and blood count testing, rather than routine measurement of B12 levels after treatment has started

Many users remain at 10mg as their maintenance dose rather than escalating further

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