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In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself

Water retention or mild bloating: Small amounts of fluid retention can occur when starting peptide analogues of growth hormone because growth hormone causes sodium and water retention in the tissues, resulting in slight puffiness or bloating

Its a controlled substance in the United States because it has the potential to be misused, and its approved for use for up to 12 weeks, the Mayo Clinic says

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Our physicians modify protocols as needed based on your response and evolving wellness objectives

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