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Mayo Clinic Proceedings

22 In two randomized controlled trials, one with 46 and the other 63 subjects with obesity and tinnitus, a diet and exercise weight loss intervention was found to reduce tinnitus severity and improve quality of life, particularly in participants who lost 5% or more of their body weight

195 Da Small Molecule 99% NNMT 5-Amino-1MQ is a selective small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that plays a key role in cellular energy metabolism and has been linked to obesity and metabolic dysfunction

These findings are supported by gene expression data indicating upregulation of lipolytic markers and 3-adrenergic receptor transcripts