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Use conservative peptide dosing (5070% of standalone effective dose) and avoid concurrent antidepressant dose escalation

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This allows assessment of how much improvement persists after the peptide clears the system

MOTS-c and 5-Amino-1MQ target upstream metabolic pathways (AMPK activation and NAD+ preservation) that enhance energy expenditure and fat oxidation independent of appetite or intake

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It is worth restating plainly: there is no placebo-controlled human data supporting a two-to-four-week ramp, or any other timeline