The Safety Paradox The safety profile is notable enough that BPC-157 holds GRAS (Generally Recognized as Safe) status, meaning it can be sold as a supplement from a supplement store

Potential risks Serious risks and adverse events include: Allergic reaction to the medications or dye used in the injection Shoulder infection Depigmentation of the skin around the injection site (a whitening of the skin) Local fat atrophy around the injection site (thinning of the skin) Rupture of a tendon located in the path of the injection Nerve damage near the shoulder joint Bleeding at the injection site In addition to the above, corticosteroid injections increase the risk of: High blood pressure High blood sugar Decreased immune function Decrease in bone mineral density Bone infection (osteonecrosis) Reproductive hormone imbalance Metabolic changes (eg, increased appetite, weight gain, and fluid retention) These risks are typically associated with higher doses of corticosteroids, multiple injections, and for people with underlying medical conditions such as diabetes and heart problems
Any color change means something has gone wrong
By improving the contrast of colorectal lesions, methylene blue assists healthcare professionals in more accurate diagnosis and treatment planning
Timing : Near injury for BPC-157 (local), TB-500 often used in conjunction to support broader tissue repair
[DOI] [PubMed] [Google Scholar] 146.Tessari P., Cecchet D., Cosma A., Vettore M., Coracina A., Millioni R., Iori E., Puricelli L., Avogaro A., Vedovato M