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In addition, the release of Ca 2+ from the ER to the cytosol is another important player involved in the intrinsic (mitochondrial) pathway of apoptotic cell death [50, 59]

As such, it is involved in many biological processes, including the breakdown of fats, the reduction of serum cholesterol, serotonin activity modulation, gene expression, and insulin signal transduction

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10.1016/0928-4257(93)90038-u [DOI] [PubMed] [Google Scholar] Sikiric P., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., et al

Hypothyroidism has an adverse effect on human spermatogenesis: A prospective, controlled study