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Similar content being viewed by others Introduction The eyes are exposed to constant irradiation, and therefore have extraordinary need for antioxidant protection 1

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(172) demonstrated in diabetic rat models that TMAO treatment exacerbated renal inflammation and fibrosis through activation of the NLRP3 inflammasome, promoting IL-1 and IL-18 release and increasing pro-fibrotic TGF-1 expression

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Most importantly, they demonstrate efficacy against schistosome infections in mice, meeting the criteria for lead progression indicated by WHO, and outperform the previously reported efficacy of praziquantel against juvenile worms 13

10.1126/science.1202747 15 CtA