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On the other hand, suppressing ferroptosis might enhance an M2 phenotype that is anti-inflammatory, which may help decrease tissue damage and inflammation ( Depletion of glutathione peroxidase 4 (GPX4), an enzyme that lowers lipid hydroperoxides and inhibits lipid peroxidation, is the main cause of ferroptosis in macrophages (60)

Drug and Therapeutic Bulletin,1966,2,506-507 Shah AD,Wood DM,Dargan PI.Understanding lactic acidosis in paracetamol poisoning.BrJ Clin Pharmacol 2010;71:20-8 Prescott LF,Roscoe P, Wright N,Brown S.Paracetamol half life and hepatic necrosis in patients with paracetamol overdosage

Crohns Colitis 15 , 20222030 (2021)

The milk thistle/Silymarin reduces oxidative stress caused by hydrogen peroxide as well as increases the antioxidant activity of various antioxidant enzymes including GPX1

J.ChoiY.ShinS

doi:10.1359/jbmr.06s223