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When the levels of these cytotoxic agents increase, serious damage occurs through the oxidative modification of macromolecules such as lipids, proteins, and DNA, and this process occurs more frequently with age

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Metabolic reprogramming in astrocytes prevents neuronal death through a Uchl1/Pfkfb3/H4k8la positive feedback loop

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This renders the hypothesis of a Ser111/His108 hTrxR1 dyad for deprotonation of Cys497 hTrxR1 unlikely