This paper has been partly supported by funding to P.P
As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19
S., Zhang, H., Gobe, V., Asante-Donyinah, D
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Buspirone additionally activates AMPK, supporting metabolic homeostasis
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