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Tumor cell-stimulating HGF is secreted in a paracrine manner by TME-localized fibroblasts and not by the tumor cells themselves (26)
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Furthermore, owing to different reasons, a considerable number of cancer patients did not respond to these therapeutics efficiently (8,9)
These studies contribute to the broader understanding of biology and may support ongoing scientific development
For instance, BPC-157, a peptide found in gastric proteins, is used mainly for angiogenesis and local signaling studies, while TB-500, a peptide found in Thymosin Beta-4, is mostly used for actin regulation and cell migration
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