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Though this method is not typically used to measure cytokine levels as compared to the more common plasma measurements, it can be an important method of measure due to the short half-life of cytokines and their localization in production, thus many studies have utilized this alternate method (Sullivan et al., 2000

PMID: 38383406 Proc Natl Acad Sci U S A Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

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This activation can initiate an autoamplifying feedback loop, referred to as the TLR-Radical Cycle Pathway [161]