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Melatonin interacts with several medications, including blood thinners, immunosuppressants, and diabetes medications, requiring careful monitoring and potential dose adjustments

187,188 The acute post-injury phase is often followed by an inflammation-associated BBB disruption that may last several hours to weeks after injury and has been associated with worse neurological outcomes in rodent and CNS injured patients

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Thus, this review aims to provide an impulse to further investigate the prominent role of oxalate in inflammasome activation and the progression of kidney disease