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In addition, various coating materials like polyethylene glycol (PEG), poly (lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), lipids, and others have been used to modify the metal-based NP surface, which considerably changes the physicochemical properties of NPs (Tefft et al., 2015

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The best characterized TFs that have defined functions in regulating adult neurogenesis include: SRY-related high-mobility-group box 2 (Sox2), paired box gene 6 (Pax6), T-box brain gene 2 (Tbr2), RE1 silencing transcription factor (REST), achate-schute complex homolog-like 1 (Ascl1), the orphan nuclear hormone receptor tailless (TLX), cyclic AMP response element-binding protein (CREB), and neurogenic differentiation 1 (NeuroD1) [62,63,64,65,66,67,68,69]