No controlled trial comparing intra-articular AOD-9604 to placebo or standard intra-articular therapies (hyaluronic acid, corticosteroids) has been completed
subcutaneous injection)
Interestingly, both kinase DYRK1A and Akt have convergent effects by directly inactivating GSK3 by phosphorylation at Thr356 (for DYRK1A) (Song et al., 2015) and on serine 9 (for Akt) (Tlili et al., 2013
His work on the GHK-Cu peptide, in particular, has been instrumental in understanding the regenerative and protective actions of the compound
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Ishii et al., 2001
