GSH plays a key role in many biological processes, including the synthesis of proteins and DNA, the transport of amino acids, and the protection of cells against oxidation
Some of the phosphorylation sites that have been subjected to the greatest degree of study are Ser40, Ser44, Ser579, Ser585, Ser592, Ser616, Ser637, Ser656, Ser693, and other phosphorylation sites (Qi et al., 2019)
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GPX3 can clear ROS through various signaling pathways, protecting cancer cells from damage caused by exogenous oxidants while also utilizing exogenous fatty acids provided in the TME to help OCSCs to survive in the complex TME