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Converting tanshinone IIA into its sodium sulfonate form (sodium tanshinone IIA sulfonate, STS) greatly increases polarity and bioavailability, and indeed STS is used interchangeably with tanshinone IIA in studies and has been approved in China as an injectable drug (Shao et al., 2024
Zhang, C., Wu, W., Li, X., Xin, X
11,12 However, the evidence supporting TCM for tinnitus is limited by its substantial methodological shortcomings
Suggested benefits for mood, cognition, and possibly conditions like traumatic brain injury, Parkinsons disease, and depression, but these claims are not substantiated in humans358
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In humans, the biotin-requiring enzymes include acetyl-CoA carboxylase (ACC: humans express two distinct ACC genes), pyruvate carboxylase (PC), propionyl-CoA carboxylase (PCC), and 3-methylcrotonyl-CoA carboxylase (3MCC)
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