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No enzyme is necessary to form peroxynitrite, and the rate of superoxide reacting with NO (~1 10 10 M 1 s 1 ) is faster than that reacting with SOD (~2 10 9 M 1 s 1 ) [73,74]

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Most patients begin noticing subtle but consistent improvements within 3 to 6 weeks

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In an openlabel study involving 20 patients, constipation scores improved by 30%, although the absence of a control group limits interpretation [22]