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Swelling from Vitamin B12 Injections Swelling can occur not just at the injection site but also in other parts of the body, such as the ankles or feet

2 Methyl-B12 is an essential cofactor in the one-carbon methylation cycle converting homocysteine to methionine, and in the course converting methyl-tetrahydrofolate back to tetrahydrofolate

For someone who has difficulty getting enough B12 due to underlying health conditions or diet, this helps offset the need for smaller daily increments of B12 from diet or oral vitamins

People can have vitamin B12 deficiency, folate deficiency, or both

For 5-Amino-1MQ, those factors converge on injection as the method that preserves research integrity

Methylcobalamin should not be used in patients with early hereditary optic nerve atrophy (Lebers disease)