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Wu X, Li Y, Zhang S, Zhou X

Histamine, Sleep, and Circadian Rhythm: Histamine is a neurotransmitter in the brain

This pathway activation enables: Enhanced neuronal survival under stress conditions Increased dendritic arborization and synaptic density Improved axonal sprouting and regeneration Activation of neuronal repair mechanisms Studies using neuronal cell cultures revealed that Cerebrolysin significantly increases neurite outgrowth and protects against excitotoxic injury, effects attributed to neurotrophic factor-like activities[2]

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ML226 treatment did not substantially alter mitochondrial content (MitoTracker), superoxide levels (MitoSox), or mitochondrial membrane potential (TMRM