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AI and AI-assisted tools statement During the preparation of this manuscript, the AI tool ChatGPT (GPT-5, released 2025-08-07) was used to generate Figure 1 and the Graphical Abstract and to improve the readability and language of the manuscript

In aged rats with induced cognitive deficits, Dihexa restored memory performance to levels comparable to healthy young animals through structural increases in dendritic spine density

Thus, to what extent we can fit theory to the data depends on the accuracy of not only the concentrations as a function of pH, but also on the accuracy of the measured solubility of the very low solubility Nic OH species and, if available, on measuring or calculating the pKa itself

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At the end point, cells were rapidly washed with ice-cold PBS and incubated at 80 C for 30 min with extraction solvent at a ratio of 1 ml per 1 10 6 cells

doi: 10.2174/1871527320666210806165430