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Additionally, the abnormal activation of specific immune signaling cascades promotes carcinogenesis

Therefore, this mini review aims to summarize the current evidence surrounding the effect of urolithin A on biological pathways relevant to sleep health and explore possible mechanisms by which this polyphenolic metabolite could impact sleep, thereby highlighting future opportunities for research

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Enhanced macrophage apoptosis and defective efferocytosis of apoptotic cells results in necrotic cell death causing heightened inflammation leading to increased smooth cell death, decreased extracellular matrix production, and collagen degradation by macrophage proteases

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PMID: 28789631