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Description

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A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being a strong biochemical oxidizer

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Furthermore, in some tissues, extracellular glutathione needs to be degraded into individual amino acids before transportation inside the cell

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Abdul-Hadi MH, Naji MT, Shams HA, Sami OM, Al-Harchan NA-A, Al-Kuraishy HM, et al

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