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Acknowledgement This work was supported by the Key Research and Development Program of Ningxia (NO.2024BBF2015), Natural Science Foundation of Ningxia Province (NO.2022AAC03020), the Key Research and Development Program of Yinchuan (NO.2024NYHZC002), Ningxia Science and Technology Leading Talent Training Project (NO.2025.9)

However, clinical trials have shown the procedure to be highly effective

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The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

The gel complex appeared to have the potential to induce closure of 98.5% of plantar ulcers whereas the control only reportedly induced 60.8% of ulcer healing

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