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Sanyal AJ, Chalasani N, Kowdley KV, et al

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Due to irons hydrophilic properties, iron needs to traverse the BBB to enter the brain parenchyma from the circulating blood, and BBB disruption and intracranial hemorrhage in TBI patients lead to iron deposition in the brain, disrupting iron metabolism

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Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial