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10.1378/chest.12-2664 Chest

In HaCaT model, quercetin treatment was associated with increased expression of E-cadherin and occludin, upregulation of antioxidant enzymes including superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and catalase, and reduced levels of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), which may support improved keratinocyte migration and in vitro wound closure ( At the cytoskeletal level, keratins keratin 1 and keratin 10 (K1/K10) are critical structural proteins that contribute to the maintenance of epidermal mechanical integrity and barrier stability

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2000, 16: 183-197, viii

Research demonstrates that GHK-Cu stimulation of collagen synthesis begins at concentrations between 10 and 10 M and maximizes at 10 M, with effects independent of changes in cell proliferation, indicating direct activation of synthetic machinery rather than simply increasing fibroblast numbers