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Differentiation was induced by adding 2% dimethyl sulfoxide (DMSO) (Sigma-Aldrich) to the culture medium for at least two weeks as previously described 32,73

The SUSTAIN (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) trial series began enrolling patients in 2012, ultimately encompassing multiple phase 3 trials with thousands of participants worldwide

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doi: 10.1002/art.23609

As an antioxidant defense, GSH has several roles: it can directly scavenge hydroxyl radicals and peroxynitrites [14, 15]