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Ichimura Y, Waguri S, Sou Y-S, Kageyama S, Hasegawa J, Ishimura R, et al

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Given the promising anti-cancer effects of IGF-IR-targeted agents in preclinical models, clinical trials have been initiated to evaluate the efficacy of anti-IGF-IR mAbs (Table 1) [144,145,146,147,148,149,150,151]

Omics-informed drug and biomarker discovery: opportunities, challenges and future perspectives

doi: 10.1159/000119233 384 LawsonNHsiehCHMarchDWangX

Proteins, lipids, and DNA of hepatocytes are among the cellular structures that are primarily affected by the oxidant and antioxidant imbalance within the cell, which participates in the course of inflammatory, metabolic, and proliferative liver diseases