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J Anal Methods Chem

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

Blood 124 , 16261636 (2014)

Loading phase (4-6 weeks): Typical loading doses range from 2 to 2.5 mg administered twice weekly, totaling 4-5 mg per week

These findings demonstrated that ove-ECM1-MenSCs were more effective than nave MenSCs in preventing LX-2 cell activation

Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Jollow et al., 1973)