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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications

[DOI] [PMC free article] [PubMed] [Google Scholar] 209.Agradi E., Petroni A., Socini A., Galli C

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One study of 125 patients with colorectal cancer found significantly higher IGF-1 levels in those with more advanced cancers compared to those with lower grade cancers (20)