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Using alcohol, which is also a central nervous system depressant, can amplify GHBs sedative effects

Free Radic Biol Med 14:649653 Sheehan D, Meade G, Foley VM, Dowd CA (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

(In French) Reprod Nutr Dev 1988

When used together, the brightening effects of both ingredients can be tripled, resulting in maximized benefits

The pH and ionic strength of the hydration buffer also influence protein charge and folding stability