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P2Y 2 receptor agonists, denufosol (OLIYNYK et al., 2010), were promising for their ability to activate alternative chloride secretion pathways, but both of these agonists have not been pursued further due to not meeting primary study goals of improving FEV 1 (Ratjen et al., 2012) and having a narrow effective concentration range, respectively (OLIYNYK et al., 2010)

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This is where retatrutide separates itself from single and dual receptor agonists

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