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In animal models, selective removal of these cells has been associated with improved tissue morphology and regenerative capacity

Verdict: Works, but impractical, expensive, and carries real risks

C9orf72 protein can be recognized by T cells as an autoantigen, and this ALS-associated T cell autoreactivity was found broadly in ALS patients, though it was particularly high in C9orf72 mutation carriers (Michaelis et al., 2025)

Patience and regularity are key to achieving lasting, visible results

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Protective effect of glutathione against oxidative stress-induced cytotoxicity in RAW 264.7 macrophages through activating the nuclear factor erythroid 2-related factor-2/heme oxygenase-1 pathway