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Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H

Recent studies have shown that, beyond eliminating pathogens through traditional phagocytosis, neutrophils participate in anti-infective defense and inflammatory responses by releasing neutrophil extracellular traps (NETs), secreting inflammatory mediators (e.g., cytokines, chemokines, and lipid mediators), and producing ROS (103, 104)

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile