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It extends beyond a simple aging process, involving irreversible and progressive neurological degeneration that impairs brain function through multiple etiologies

Careful screening helps identify individuals for whom these therapies may pose risks or lack sufficient safety data

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Rodents fed with HFD develop increased ovarian lipid accumulation, disrupted mitochondrial function, elevated ROS production, and chronic metabolic inflammation, closely mimicking PCOS and metabolic-related reproductive impairment ( HFD-induced oxidative stress models have demonstrated the causal relationship between systemic metabolic derangements and ovarian damage

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Cells were grown to 90-100% confluency before use